MicroRNA-886-3P functions as a tumor suppressor in small cell lung cancer
نویسندگان
چکیده
منابع مشابه
MicroRNA-409-3p functions as a tumor suppressor in human lung adenocarcinoma by targeting c-Met.
BACKGROUND/AIMS Dysregulation of microRNAs is correlated with tumor development. The aim of this study is to investigate the clinicopathologic and prognostic significance of microRNA (miR)-409-3p and its tumor suppressor roles in lung adenocarcinoma (LAD). METHODS Quantitative real-time PCR (qRT-PCR) was performed to detect miR-409-3p expression in LAD tissues and corresponding noncancerous t...
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MicroRNA (miR)-138 was found to have suppressive effects on the growth and metastasis of different human cancers. In this study, we aimed to investigate the regulatory mechanism of miR-138 in non-small cell lung cancer (NSCLC). We applied the Quantitative real-time PCR (qRT-PCR) to detect the miR-138 levels in NSCLC tissues (n=21) and cell lines, Bioinformatical predication, luciferase reporter...
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BACKGROUND/AIMS Abnormal expression of microRNA-124 (miR-124) was found in non-small cell lung cancer (NSCLC). However, the association between miR-124 and CDH2 has not been reported yet. This study aims to reveal the inhibiting effects of miR-124 on the expression of CDH2 in NSCLC. METHODS Quantitative real-time polymerase chain reaction was used to evaluate the expression of miR-124 and CDH...
متن کاملP42 Ebp1 functions as a tumor suppressor in non-small cell lung cancer
Although the short isoform of ErbB3-binding protein 1 (Ebp1), p42 has been considered to be a potent tumor suppressor in a number of human cancers, whether p42 suppresses tumorigenesis of lung cancer cells has never been clarified. In the current study we investigated the tumor suppressor role of p42 in non-small cell lung cancer cells. Our data suggest that the expression level of p42 is inver...
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ژورنال
عنوان ژورنال: Cancer Biology & Therapy
سال: 2018
ISSN: 1538-4047,1555-8576
DOI: 10.1080/15384047.2018.1491505